Search results for: Jeffrey C. Kurz

Items from 1 to 6 out of 6 results

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Protein–Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5′ Leaders by Bacterial Ribonuclease P

Kristin S. Koutmou, Nathan H. Zahler, Jeffrey C. Kurz, Frank E. Campbell, more

Journal of Molecular Biology > 2010 > 396 > 1 > 195-208

Bacterial ribonuclease P (RNase P) catalyzes the cleavage of 5′ leader sequences from precursor tRNAs (pre-tRNAs). Previously, all known substrate nucleotide specificities in this system are derived from RNA–RNA interactions with the RNase P RNA subunit. Here, we demonstrate that pre-tRNA binding affinities for Bacillus subtilis and Escherichia coli RNase P are enhanced by sequence-specific contacts...

article

Pharmacologic and Pharmacokinetic Assessment of Anti-TGFβ2 Aptamers in Rabbit Plasma and Aqueous Humor

Thomas G. McCauley, Jeffrey C. Kurz, Patricia G. Merlino, Scott D. Lewis, more

Pharmaceutical Research > 2006 > 23 > 2 > 303-311

Purpose The aim of the study is to determine the bioactivity and effects of PEGylation on the pharmacokinetics in rabbit aqueous humor and plasma of an aptamer directed against TGFβ2. Methods Pharmacological activity of anti-TGFβ2 aptamer in rabbit ocular fluid was demonstrated using a mink lung epithelial cell proliferation assay. For pharmacokinetic analyses, concentrations of aptamers in plasma...

article

Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

Paula E. Burmeister, Scott D. Lewis, Robert F. Silva, Jeffrey R. Preiss, more

Chemistry & Biology > 2005 > 12 > 1 > 25-33

Aptamers (protein binding oligonucleotides) have potential as a new class of targeted therapeutics. For applications requiring chronic systemic administration, aptamers must achieve high-affinity target binding while simultaneously retaining high in vivo stability, tolerability, and ease of chemical synthesis. To this end, we describe a method for generating aptamers composed entirely of 2′-O-methyl...

article

The Affinity of Magnesium Binding Sites in the Bacillus subtilis RNase P·Pre-tRNA Complex Is Enhanced by the Protein Subunit ^†

Jeffrey C. Kurz, Carol A. Fierke

Biochemistry > 2002 > 41 > 30 > 9545 - 9558

article

Linked Folding and Anion Binding of the Bacillus subtilis Ribonuclease P Protein ^†

Christopher H. Henkels, Jeffrey C. Kurz, Carol A. Fierke, Terrence G. Oas

Biochemistry > 2001 > 40 > 9 > 2777 - 2789

article

Ribonuclease P: a ribonucleoprotein enzyme

Jeffrey C Kurz, Carol A Fierke

Current Opinion in Chemical Biology > 2000 > 4 > 5 > 553-558

The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5' end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA-P-protein and RNase-P-RNA-precursor-tRNA complexes, as well as on the positions of catalytic metal ions, emphasizing the importance of the structure to the catalytic function.

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Search results for: Jeffrey C. Kurz

Protein–Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5′ Leaders by Bacterial Ribonuclease P

Pharmacologic and Pharmacokinetic Assessment of Anti-TGFβ2 Aptamers in Rabbit Plasma and Aqueous Humor

Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

The Affinity of Magnesium Binding Sites in the Bacillus subtilis RNase P·Pre-tRNA Complex Is Enhanced by the Protein Subunit ^†

Linked Folding and Anion Binding of the Bacillus subtilis Ribonuclease P Protein ^†

Ribonuclease P: a ribonucleoprotein enzyme

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INFONA - science communication portal

Search results for: Jeffrey C. Kurz

Protein–Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5′ Leaders by Bacterial Ribonuclease P

Pharmacologic and Pharmacokinetic Assessment of Anti-TGFβ2 Aptamers in Rabbit Plasma and Aqueous Humor

Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

The Affinity of Magnesium Binding Sites in the Bacillus subtilis RNase P·Pre-tRNA Complex Is Enhanced by the Protein Subunit †

Linked Folding and Anion Binding of the Bacillus subtilis Ribonuclease P Protein †

Ribonuclease P: a ribonucleoprotein enzyme

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The Affinity of Magnesium Binding Sites in the Bacillus subtilis RNase P·Pre-tRNA Complex Is Enhanced by the Protein Subunit ^†

Linked Folding and Anion Binding of the Bacillus subtilis Ribonuclease P Protein ^†