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We investigated parabutoporin (PP), an antimicrobial scorpion peptide, to understand its inhibition on NADPH oxidase in human PMN. We show that PP is a good substrate for all PKC-isotypes, implicated in the activation of NADPH oxidase, and acts as a potent competitive inhibitor of in vitro p47 phox -phosphorylation by PKC-α, -βI, -βII and -δ, but not PKC-ζ. In PMN, PP also inhibits the PMA-stimulated...
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