Search results for: John K. Bielicki

Modulation of the reverse cholesterol transport (RCT) pathway may provide a therapeutic target for the prevention and treatment of atherosclerotic cardiovascular disease (CVD). In the present study, we evaluated a novel 26-amino acid apolipoprotein mimetic peptide (ATI-5261) designed from the carboxyl terminal of apoE, in its ability to mimic apoA-I functionality in RCT in vitro. Our data shows that...

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A pyrene based fluorescence approach to study conformation of apolipoprotein E3 in macrophage-generated nascent high density lipoprotein

Sea H. Kim, Shweta Kothari, Arti B. Patel, John K. Bielicki, more

Biochemical and Biophysical Research Communications > 2014 > 450 > 1 > 124-128

Apolipoprotein E3 (apoE3) is an anti-atherogenic apolipoprotein with the ability to exist in lipid-free and lipoprotein-associated states. During atherosclerosis, its function in promoting cholesterol efflux from macrophages via the ATP-binding cassette transporter A1 (ABCA1) takes a prominent role, leading to generation of nascent high density lipoprotein (nHDL) particles. The objective of this study...

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COGPEP™, AN APOE-DERIVED ABCA1 AGONIST PEPTIDE, REVERSES ALZHEIMER'S DISEASE PHENOTYPE IN HUMAN APOE4 REPLACEMENT MICE

Anat Boehm-Cagan, Jan O. Johansson, John K. Bielicki, Danny Michaelson

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P921

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Analysis of the Molecular Organization of Lipoprotein-Associated Apolipoprotein E, an Anti-Atherogenic Protein

Shweta Kothari, Sea H. Kim, Arti B. Patel, John K. Bielicki, more

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 712a

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Retention of α-helical structure by HDL mimetic peptide ATI-5261 upon extensive dilution represents an important determinant for stimulating ABCA1 cholesterol efflux with high efficiency

Ying Zheng, Arti B. Patel, Vasanthy Narayanaswami, John K. Bielicki

Biochemical and Biophysical Research Communications > 2013 > 441 > 1 > 71-76

ATI-5261 is a novel, single-helix peptide that stimulates cellular cholesterol efflux with high potency similar to native apolipoproteins on a molar basis. Presently we investigated structural features of the peptide that conferred cholesterol efflux activity. Analogs of ATI-5261 with amino acids arranged in reverse order or with individual arginine (R) to glutamine (Q) substitutions (i.e. R3Q, R14Q,...

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HDL Mimetic Peptide ATI-5261 Forms an Oligomeric Assembly in Solution That Dissociates to Monomers upon Dilution

Ying Zheng, Arti B. Patel, Vasanthy Narayanaswami, Gregory L. Hura, more

Biochemistry > 2011 > 50 > 19 > 4068 - 4076

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The C-Terminal Lipid-Binding Domain of Apolipoprotein E Is a Highly Efficient Mediator of ABCA1-Dependent Cholesterol Efflux that Promotes the Assembly of High-Density Lipoproteins ^†

Charulatha Vedhachalam, Vasanthy Narayanaswami, Nicole Neto, Trudy M. Forte, more

Biochemistry > 2007 > 46 > 10 > 2583 - 2593

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Combined N- and C-Terminal Truncation of Human Apolipoprotein A-I Yields a Folded, Functional Central Domain ^†

Jennifer A. Beckstead, Brian L. Block, John K. Bielicki, Cyril M. Kay, more

Biochemistry > 2005 > 44 > 11 > 4591 - 4599

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Structure−Function Studies of Human Apolipoprotein A-V: A Regulator of Plasma Lipid Homeostasis ^†

Jennifer A. Beckstead, Michael N. Oda, Dale D. O. Martin, Trudy M. Forte, more

Biochemistry > 2003 > 42 > 31 > 9416 - 9423

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Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I _M _i _l _a _n _o

Zhen Jia, Pradeep Natarajan, Trudy M. Forte, John K. Bielicki

Biochemical and Biophysical Research Communications > 2002 > 297 > 2 > 206-213

Apolipoprotein(apo)A-I _M _i _l _a _n _o (R173C) and apoA-I _P _a _r _i _s (R151C) are rare cysteine variants of wild-type (WT) apoA-I that possess novel antioxidant properties on phospholipid surfaces. Yet, the two variants differ in their ability to inhibit lipid peroxidation. In this study, we used synthetic peptides (18mers) to investigate the structural...

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Apolipoprotein A-I _Milano and Apolipoprotein A-I _Paris Exhibit an Antioxidant Activity Distinct from That of Wild-Type Apolipoprotein A-I ^†

John K. Bielicki, Michael N. Oda

Biochemistry > 2002 > 41 > 6 > 2089 - 2096

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Paraoxonase 1 Overexpression in Mice and Its Effect on High-Density Lipoproteins

Michael N. Oda, John K. Bielicki, Tamara T. Ho, Trish Berger, more

Biochemical and Biophysical Research Communications > 2002 > 290 > 3 > 921-927

Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme believed to protect against the early events of atherogenesis by its ability to hydrolyze oxidized phospholipids. A transgenic mouse overexpressing PON1 (mPON1) was developed to address the question of whether overexpression of PON1 is important in protecting HDL function during oxidative stress. Transgenic mice were obtained...

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Relative sensitivities of plasma lecithin:cholesterol acyltransferase, platelet-activating factor acetylhydrolase, and paraoxonase to in vitro gas-phase cigarette smoke exposure

John K. Bielicki, Laura J. Knoff, Diane L. Tribble, Trudy M. Forte

Atherosclerosis > 2001 > 155 > 1 > 71-78

In order to identify potential atherogenic properties of gas-phase cigarette smoke, we utilized an in vitro exposure model to determine whether the activities of several putative anti-atherogenic enzymes associated with plasma lipoproteins were compromised. Exposure of heparinized human plasma to gas-phase cigarette smoke produced a dose-dependent reduction in the activity of platelet-activating factor...

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Cysteine Substitutions in Apolipoprotein A-I Primary Structure Modulate Paraoxonase Activity ^†

Michael N. Oda, John K. Bielicki, Trish Berger, Trudy M. Forte

Biochemistry > 2001 > 40 > 6 > 1710 - 1718

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Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme's free thiols

John K. Bielicki, Trudy M. Forte, Mark R. McCall

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism > 1995 > 1258 > 1 > 35-40

Cigarette smoking is associated with an increased risk of premature atherosclerosis. The underlying mechanisms responsible for this association are unknown. Recent work from this laboratory has shown that ex vivo exposure of plasma to gas-phase cigarette smoke (CS) produces a rapid inhibition of lecithin-cholesterol acyltransferase (LCAT) activity and crosslinking of HDL-apolipoproteins. The goal...

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