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An aspartate residue in the M2-M3 loop of neuronal nicotinic receptor α 7 subunits is a major determinant of the channel functional response. This residue is conserved in most β 4 subunits, e.g. human and rat, but not in others, e.g. bovine. We have used these differences to examine the mechanism by which this residue alters the functional properties of α 3 β 4 receptors...
The neuronal nicotinic acetylcholine receptor (nAChR) subunits α3 and α7 have different assembly behavior when expressed in heterologous expression systems: α3 subunits require other subunits to assemble functional nAChRs, whereas α7 subunits can produce homomeric nAChRs. A previous analysis of α7/α3 chimeric constructs identified a domain comprising the first putative membrane-spanning segment,...
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