Search results for: Ronald A. Li

Items from 1 to 20 out of 62 results

article

Ultra‐Compliant Indwelling Elastomer Balloons Improve Stability and Performance of Bioengineered Human Mini‐Hearts

Erin G. Roberts, Suet Yee Mak, Andy On-Tik Wong, David D. Tran, more

Advanced Engineering Materials > 24 > 8 > n/a - n/a

Animal models used by the pharmaceutical industry to define drug safety and efficacy are expensive, resource‐intensive, subject to interspecies differences, and often fail to predict human responses. Therefore, engineered human tissue preparations are gaining importance as in vitro models to address translation from preclinical data to clinical outcome. Methods that improve fabrication consistency,...

article

A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Junmin Lee, Shreya Mehrotra, Elaheh Zare‐Eelanjegh, Raquel O. Rodrigues, more

Small > 17 > 15 > n/a - n/a

Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early signs of CIC. Moreover, breast cancer (BC) patients with preexisting cardiac dysfunctions may lead to different incident levels of CIC. Here, a model...

article

Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021)

Junmin Lee, Shreya Mehrotra, Elaheh Zare‐Eelanjegh, Raquel O. Rodrigues, more

Small > 17 > 15 > n/a - n/a

In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immuno‐aptasensors to monitor cell‐secreted multiple biomarkers, the proposed platform could be potentially...

article

A Small‐Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies

Ming‐Yu Wu, Jong‐Kai Leung, Li Liu, Chuen Kam, more

Angewandte Chemie International Edition > 59 > 26 > 10327 - 10331

The chromosome periphery (CP) is a complex network that covers the outer surface of chromosomes. It acts as a carrier of nucleolar components, helps maintain chromosome structure, and plays an important role in mitosis. Current methods for fluorescence imaging of CP largely rely on immunostaining. We herein report a small‐molecule fluorescent probe, ID‐IQ, which possesses aggregation‐induced emission...

article

A Small‐Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies

Ming‐Yu Wu, Jong‐Kai Leung, Li Liu, Chuen Kam, more

Angewandte Chemie > 132 > 26 > 10413 - 10417

article

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application

Shreya Mehrotra, Bruna A. G. Melo, Minoru Hirano, Wendy Keung, more

Advanced Functional Materials > 30 > 12 > n/a - n/a

Bioprinting holds great promise toward engineering functional cardiac tissue constructs for regenerative medicine and as drug test models. However, it is highly limited by the choice of inks that require maintaining a balance between the structure and functional properties associated with the cardiac tissue. In this regard, a novel and mechanically robust biomaterial‐ink based on nonmulberry silk...

article

Myocardial Tissue Engineering: Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application (Adv. Funct. Mater. 12/2020)

Shreya Mehrotra, Bruna A. G. Melo, Minoru Hirano, Wendy Keung, more

Advanced Functional Materials > 30 > 12 > n/a - n/a

In article number 1907436, Biman B. Mandal, Su Ryon Shin, and co‐workers develop a non‐mulberry silk‐based ink for fabricating tough and flexible cardiac patches. The silk‐based ink has also facilitated the development of 3D endothelialized myocardial constructs that could potentially be used for an organ‐on‐a‐chip model as a drug screening platform.

article

Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-11

Background Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy, dilated cardiomyopathy, and conduction system abnormalities in FRDA lead to cardiomyocyte (CM) death and fibrosis, consequently resulting in heart failure and arrhythmias. Murine...

article

AAV-mediated conversion of human pluripotent stem cell-derived pacemaker

Patrick K.W. Chan, Lin Geng, Yi Gao, Wendy Keung, more

Biochemical and Biophysical Research Communications > 2017 > 494 > 1-2 > 346-351

Malfunction of nodal pacemaker (Pm) cardiomyocytes (CMs) due to diseases or aging leads to rhythm generation disorders, necessitating electronic Pm implantation. We functionally reprogrammed human pluripotent stem cell (hPSC) derived-ventricular (V) CMs into -PmCMs via recombinant adeno-associated virus serotype 9 (rAAV9)-mediated overexpression of engineered HCN1 channel (HCN1ΔΔΔ) whose S3-S4 linker...

article

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification

Eugene K. Lee, David D. Tran, Wendy Keung, Patrick Chan, more

Stem Cell Reports > 2017 > 9 > 5 > 1560-1572

Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-derived cardiomyocytes and three-dimensional engineered cardiac tissue constructs to better recapitulate human heart function and drug responses. As these...

article

An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients

Jun Lu, Yee-Ki Lee, Xinru Ran, Wing-Hon Lai, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2017 > 1863 > 11 > 2964-2972

Dilated cardiomyopathy (DCM) is cardiac disease characterized by increased left ventricular chamber volume and decreased systolic function. DCM patient-specific human induced-pluripotent stem cells-derived cardiomyocytes (DCM-hiPSC-CMs) were generated. We found that uniaxial stretch elicited a cytosolic [Ca²⁺]_i rise in hiPSC-CMs. Compared to control-hiPSC-CMs, DCM-hiPSC-CMs displayed a greater magnitude...

article

A Singular Role of I_K1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by I_K1–Induced Activation of Pacemaker Current

Yu Sun, Valeriy Timofeyev, Adrienne Dennis, Emre Bektik, more

Stem Cell Reviews and Reports > 2017 > 13 > 5 > 631-643

The inward rectifier potassium current (I_K1) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that I_K1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (I_f) in adult ventricular cardiomyocytes (CMs). However, the intriguing ability of I_K1 to activate I_f and thereby promote automaticity...

article

Increasing the physical size and nucleation status of human pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion

Chi-Wing Kong, Shuxun Chen, Lin Geng, Angie Man-Yee Shum, more

Stem Cell Research > 2017 > 19 > C > 76-81

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) provide an unlimited source of donor cells for potential cardiac regenerative therapies. However, hPSC-CMs are immature. For instance, hPSC-CMs are only 1/10 of the physical size of their adult counterparts; the majority are mono- rather than bi- or multi-nucleated, which is an evolutionary adaptive feature in metabolically active cells...

article

A Micropatterned Human Pluripotent Stem Cell‐Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug‐Induced Arrhythmogenicity

Angie M. Y. Shum, Hui Che, Andy On‐Tik Wong, Chenzi Zhang, more

Advanced Materials > 29 > 1 > n/a - n/a

A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well‐characterized human pluripotent stem‐cell‐derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features of native human ventricle, which, along with specific selection criteria, allows for a direct visualization of arrhythmic spiral...

article

A High-Throughput Automated Microinjection System for Human Cells With Small Size

Yu Ting Chow, Shuxun Chen, Chong Liu, Chichi Liu, more

IEEE/ASME Transactions on Mechatronics > 2016 > 21 > 2 > 838 - 850

This paper presents the development of an automated microinjection system with high productivity for small cells. Compared with many existing microinjection systems that are primarily designed for relatively large-scaled biological samples, the reported technology will enable an automated injection into the cells with a diameter smaller than 25 μm, which is the typical size of many human cells. Microfluidic...

chapter

MicroRNA and Pluripotent Stem Cell-Based Heart Therapies: The Electrophysiological Perspective

Ellen Poon, Deborah K. Lieu, Ronald A. Li

Heart Rate and Rhythm > Mechanisms of Acquired Arrhythmia > 365-383

MicroRNAs (miRs) are nonencoding RNAs that function as negative transcriptional regulators via degradation or inhibition by RNA interference. Recent studies have demonstrated that miRs are important regulators of cardiovascular cell differentiation, growth, proliferation, and apoptosis. Specifically, miRs modulate electrophysiological properties such as automaticity, conduction, and membrane repolarization...

article

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells

Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, more

BMC Cancer > 2016 > 16 > 1 > 1-9

Background Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer cell-like characteristics. Thus, tumor-initiating cell-like cells are generated...

article

Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes

Yan Qi, Zhichao Li, Chi-Wing Kong, Nelson L. Tang, more

Journal of Molecular and Cellular Cardiology > 2015 > 87 > C > 65-73

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in culture are randomly organized and do not typically show directional alignment. In the present study, we used uniaxial cyclic stretch to facilitate the alignment of cultured human embryonic stem cell-derived cardiomyocytes (hESC-CMs), so that these cells can be more adult-like for potential future application in drug screening and in...

article

Engineering a Freestanding Biomimetic Cardiac Patch Using Biodegradable Poly(lactic‐co‐glycolic acid) (PLGA) and Human Embryonic Stem Cell‐derived Ventricular Cardiomyocytes (hESC‐VCMs)

Yin Chen, Junping Wang, Bo Shen, Camie W. Y. Chan, more

Macromolecular Bioscience > 15 > 3 > 426 - 436

Microgrooved thin PLGA film (≈30 μm) is successfully fabricated on a Teflon mold, which could be readily peeled off and is used for the construction of a biomimetic cardiac patch. The contraction of it is studied with optical mapping on transmembrane action potential. Our results suggest that steady‐state contraction could be easily established on it under regular electrical stimuli. Besides, the...

chapter

Development of a high throughput robot-aided cell injection system for human cells

Yu Ting Chow, Shuxun Chen, Chong Liu, Shuk Han Cheng, more

2014 IEEE International Conference on Robotics and Automation (ICRA) > 963 - 968

2014 IEEE International Conference on Robotics and Automation (ICRA)

Few of the current injection technologies can be applied to those human cells whose diameters are ranged about 10–25 (im only. This paper reports our most recent effort in developing a robot-aided microinjection system to solve the challenging problem of automated injection on human cells. A unique microfluidic cell holding chip is designed and fabricated to trap the single cells in the predefined...

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INFONA - science communication portal

Search results for: Ronald A. Li

Ultra‐Compliant Indwelling Elastomer Balloons Improve Stability and Performance of Bioengineered Human Mini‐Hearts

A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021)

A Small‐Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies

A Small‐Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application

Myocardial Tissue Engineering: Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application (Adv. Funct. Mater. 12/2020)

Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

AAV-mediated conversion of human pluripotent stem cell-derived pacemaker

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification

An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients

A Singular Role of I_K1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by I_K1–Induced Activation of Pacemaker Current

Increasing the physical size and nucleation status of human pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion

A Micropatterned Human Pluripotent Stem Cell‐Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug‐Induced Arrhythmogenicity

A High-Throughput Automated Microinjection System for Human Cells With Small Size

MicroRNA and Pluripotent Stem Cell-Based Heart Therapies: The Electrophysiological Perspective

Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells

Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes

Engineering a Freestanding Biomimetic Cardiac Patch Using Biodegradable Poly(lactic‐co‐glycolic acid) (PLGA) and Human Embryonic Stem Cell‐derived Ventricular Cardiomyocytes (hESC‐VCMs)

Development of a high throughput robot-aided cell injection system for human cells

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