Search results for: Ricardo M. Richardson

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Proline Substitution of Dimer Interface β-strand Residues as a Strategy for the Design of Functional Monomeric Proteins

Prem Raj B. Joseph, Krishna Mohan Poluri, Pavani Gangavarapu, Lavanya Rajagopalan, more

Biophysical Journal > 2013 > 105 > 6 > 1491-1501

Proteins that exist in monomer-dimer equilibrium can be found in all organisms ranging from bacteria to humans; this facilitates fine-tuning of activities from signaling to catalysis. However, studying the structural basis of monomer function that naturally exists in monomer-dimer equilibrium is challenging, and most studies to date on designing monomers have focused on disrupting packing or electrostatic...

article

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†

Ricardo M. Richardson, Robin J. Marjoram, Alastair J. Barr, Ralph Snyderman

Biochemistry > 2001 > 40 > 12 > 3583 - 3588

article

Function and regulation of chemoattractant receptors

Bodduluri Haribabu, Ricardo M. Richardson, Margrith W. Verghese, Alastair J. Barr, more

Immunologic Research > 2000 > 22 > 2-3 > 271-279

Phagocyte migration and activation at sites of inflammation is mediated through chemoattractant receptors that are coupled to G-proteins. Early studies from our laboratory demonstrated G-protein-mediated phospholipase C activation by chemoattractants. Recently, this laboratory developed cellular and animal models to allow biochemical, cell biological and molecular genetic approaches to be used in...

article

Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors

M. Marlene Hosey, Jeffrey L. Benovic, Shubhik K. DebBurman, Ricardo M. Richardson

Life Sciences > 1995 > 56 > 11-12 > 951-955

Agonists induce phosphorylation of m2 muscarinic receptors (mAChR) in several cell types. This phosphorylation correlates with desensitization. The mechanisms underlying mAChR phosphorylation have been investigated using several in vitro approaches. Protein kinase C phosphorylated the purified and reconstituted m2 mAChR to a stoichiometry of approximately 5 mols P/mol receptor; this phosphorylation...

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Search results for: Ricardo M. Richardson

Proline Substitution of Dimer Interface β-strand Residues as a Strategy for the Design of Functional Monomeric Proteins

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses †

Function and regulation of chemoattractant receptors

Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors

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RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†