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The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth...
Das Hämaufnahmeprotein von P. aeruginosa (HasAp), mit der Form eines Fisches, nimmt auch verschiedene synthetische Eisenkomplexe, wie Eisen‐Salophene und Eisen‐Phthalocyanine, auf. In ihrer Zuschrift auf S. 2906 ff. zeigen O. Shoji, Y. Watanabe und Mitarbeiter, welche Auswirkungen die Bindung von HasAp an diese nichtnatürlichen Eisenkomplexe auf das Wachstum von P. aeruginosa und die HasAp‐vermittelte...
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