Search results for: Seungpyo Hong

Items from 1 to 20 out of 59 results

article

Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway

Ji‐Won Seo, Seongin Jo, Young Sung Jung, Mohammad‐Al Mijan, more

Rosa gallica has been previously reported to display anti‐inflammatory, anti‐oxidative, and anti‐skin wrinkle activities. However, the effect of Rosa gallica on skin hydration and its active components are largely unknown. Herein, we aimed to investigate the skin hydration effect of rose petal extract (RPE) in humans and elucidate the underlying molecular mechanism. A double‐blinded clinical study...

article

Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti‐PDL1 efficacy in head and neck cancer

Kourtney L. Kostecki, Mari Iida, Anne L. Wiley, Stanley Kimani, more

Head & Neck > 45 > 5 > 1255 - 1271

Background The tyrosine kinase receptors Axl and MerTK are highly overexpressed in head and neck cancer (HNC) cells, where they are critical drivers of survival, proliferation, metastasis, and therapeutic resistance. Methods We investigated the role of Axl and MerTK in creating an immunologically “cold” tumor immune microenvironment (TIME) by targeting both receptors simultaneously with a small...

article

Branched, dendritic, and hyperbranched polymers in liquid biopsy device design

Michael J. Poellmann, Piper Rawding, DaWon Kim, Jiyoon Bu, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 14 > 3 > n/a - n/a

The development of minimally invasive tests for cancer diagnosis and prognosis will aid in the research of new treatments and improve survival rates. Liquid biopsies seek to derive actionable information from tumor material found in routine blood samples. The relative scarcity of tumor material in this complex mixture makes isolating and detecting cancerous material such as proteins, circulating tumor...

article

Cross‐decoration of dendritic cells by non‐inherited maternal antigen‐containing extracellular vesicles: Potential mechanism for PD‐L1‐based tolerance in cord blood and organ transplantation

Diego A. Lema, Ewa Jankowska‐Gan, Ashita Nair, Sami B. Kanaan, more

American Journal of Transplantation > 22 > 5 > 1329 - 1338

Exposure to non‐inherited maternal antigens (NIMA) during the fetal period induces lifelong split tolerance to grafts expressing these allo‐antigens. In adult mice, the production of extracellular vesicles (EVs) from maternal microchimeric cells causes cross‐decoration (XD) of offspring dendritic cells (DC) with NIMA and upregulation of PD‐L1, contributing to NIMA tolerance. To see how this may apply...

article

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Piper A. Rawding, Jiyoon Bu, Jianxin Wang, Da Won Kim, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 14 > 2 > n/a - n/a

Cancer immunotherapy, or the utilization of a patient's own immune system to treat cancer, has shifted the paradigm of cancer treatment. Despite meaningful responses being observed in multiple studies, currently available immunotherapy platforms have only proven effective to a small subset of patients. To address this, nanoparticles have been utilized as a novel carrier for immunotherapeutic drugs,...

article

Gold nanoparticles in virus detection: Recent advances and potential considerations for SARS‐CoV‐2 testing development

Jianxin Wang, Adam J. Drelich, Caroline M. Hopkins, Sandro Mecozzi, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 14 > 1 > n/a - n/a

Viruses are infectious agents that pose significant threats to plants, animals, and humans. The current coronavirus disease 2019 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has spread globally and resulted in over 2 million deaths and immeasurable financial losses. Rapid and sensitive virus diagnostics become crucially important in controlling the spread...

article

Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Zhaoting Li, Yixin Wang, Jun Liu, Piper Rawding, more

Advanced Materials > 33 > 38 > n/a - n/a

Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria‐based delivery systems...

article

Tumor penetration of Sub-10 nm nanoparticles: effect of dendrimer properties on their penetration in multicellular tumor spheroids

Jason Bugno, Michael J. Poellmann, Karol Sokolowski, Hao-jui Hsu, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2019 > 21 > C

Ultrasmall nanoparticles (NPs, <10 nm) have promise in cancer treatment, yet little is known about how NP physical properties influence penetration through solid tumors. To elucidate the role of NP size and structure, we prepared a series of sub-10 nm poly(amidoamine) (PAMAM) dendrimers and gold NPs (AuNP), and evaluated penetration in multicellular tumor spheroids (MCTS). Smaller generation 2...

article

Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

Woo-jin Jeong, Jiyoon Bu, Luke J. Kubiatowicz, Stephanie S. Chen, more

Nano Convergence > 2018 > 5 > 1 > 1-18

Peptide–nanoparticle conjugates (PNCs) have recently emerged as a versatile tool for biomedical applications. Synergism between the two promising classes of materials allows enhanced control over their biological behaviors, overcoming intrinsic limitations of the individual materials. Over the past decades, a myriad of PNCs has been developed for various applications, such as drug delivery, inhibition...

article

35.1: Blue‐Diode Laser Annealing of Amorphous Silicon Films for Low‐Cost, Large‐Scale Manufacturing of Advanced Displays

Minok Park, Seungpyo Hong, Y.H. Jung, Suhui Lee, more

SID Symposium Digest of Technical Papers > 49 > S1 > 378 - 381

Blue diode laser annealing (BLA) systems have been successfully developed for low‐temperature crystallization from amorphous silicon film on glass substrates. It is demonstrated that it can achieve high quality poly‐Si film with large grain sizes, as studied by optical microscopy, Raman spectroscopy and AFM measurements. The p‐channel poly‐Si TFT on glass using BLA exhibited the field‐effect mobility...

article

Dendritic PEG outer shells enhance serum stability of polymeric micelles

Hao-jui Hsu, Yanxiao Han, Michael Cheong, Petr Král, more

Nanomedicine: Nanotechnology, Biology and Medicine > 2018 > 14 > 6 > 1879-1889

A higher surface density of poly(ethylene glycol) (PEG) on polymeric micelles enhances their stability in serum, leading to improved plasma circulation. To obtain fundamental, mechanistic understanding of the PEG effect associated with polymeric architecture/configuration, we have synthesized PEGylated dendron-based copolymers (PDCs) and linear block copolymers (LBCs) with similar molecular weights...

article

57‐2: Scalable Crystallization of a‐Si Film on a Glass Substrate by Using a Blue Laser

Minok Park, Seungpyo Hong, Y.H. Jung, Suhui Lee, more

SID Symposium Digest of Technical Papers > 49 > 1 > 751 - 754

A continuous‐wave blue laser annealing (BLA) system (λ ~ 440 nm) is applied to delineate the physical phenomenon of low‐temperature crystallization from amorphous Si (a‐Si) thin film to poly‐Si film on glass substrates for potential industrial application. At various scanning speeds and laser intensities, crystallization mechanism of BLA has been studied. It shows that BLA can achieve high quality,...

article

KRDS: a web server for evaluating drug resistance mutations in kinases by molecular docking

Aeri Lee, Seungpyo Hong, Dongsup Kim

Journal of Cheminformatics > 2018 > 10 > 1 > 1-10

Kinases are major targets of anti-cancer therapies owing to their importance in signaling processes that regulate cell growth and proliferation. However, drug resistance has emerged as a major obstacle to cancer therapy. Resistance to drugs has various underlying mechanisms, including the acquisition of mutations at drug binding sites and the resulting reduction in drug binding affinity. Therefore,...

article

Dendrimer‐based nanocarriers: a versatile platform for drug delivery

Hao‐Jui Hsu, Jason Bugno, Seung‐ri Lee, Seungpyo Hong

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 9 > 1 > n/a - n/a

Advances in nanotechnology have had profound impacts on therapeutic delivery, leading to the development of nanomaterials engineered with large carrying capabilities and targeting functionalities. Among the nanomaterials, dendrimers have garnered particular attention from researchers owing to their well‐defined structure, near‐monodispersity, and ease of multifunctionalization. As hyperbranched, three‐dimensional...

article

Low temperature polycrystalline silicon with single orientation on glass by blue laser annealing

Seonghyun Jin, Seungpyo Hong, Mallory Mativenga, Boram Kim, more

Thin Solid Films > 2016 > 616 > C > 838-841

We report the achievement of low-temperature polycrystalline silicon (LTPS) thin-films with a single orientation on glass by using continuous wave blue laser annealing (BLA) of amorphous silicon (a-Si). The BLA is administered in multiple shots and with increasing number of shots, grain size increases and all grains follow a single orientation. Because the absorption coefficient of a blue laser (BL)...

article

Single plasmonic nanoparticles for ultrasensitive DNA sensing: From invisible to visible

Longhua Guo, Lichan Chen, Seungpyo Hong, Dong-Hwan Kim

Biosensors and Bioelectronics > 2016 > 79 > C > 266-272

The background signal is a major factor that restricts the limit of detection of biosensors. Herein, we present a zero-background DNA-sensing approach that utilizes enzyme-guided gold nanoparticle (AuNP) enlargement. This sensing strategy is based on the finding that small nanoparticles are invisible under a darkfield optical microscope, thus completely eliminating the background signal. In the event...

chapter

Acquiring a Physical World and Serving Its Mirror World Simultaneously

Seungpyo Hong, Jong-gil Ahn, Heedong Ko, Jinwook Kim

Lecture Notes in Computer Science > Virtual and Mixed Reality > Vision in Virtual and Mixed Reality > 445-453

A mirror world, which is a virtual space modeling a physical space, attracts enormous interests from VR community recently. Various applications such as Second Life, Google Earth and Virtual Earth have proven their usefulness and potentialities. We introduce a novel method to build a mirror world by acquiring environment data represented as a point cloud. Since our system provides a streaming service...

article

Cover Image, Volume 8, Issue 2

Ja Hye Myung, Kevin A. Tam, Sin‐jung Park, Ashley Cha, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 8 > 2 > i - i

The cover image, by Seungpyo Hong et al., is based on the Advanced Review Recent Advances in Nanotechnology‐based Detection and Separation of Circulating Tumor Cells, DOI: 10.1002/wnan.1360.

article

Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Ja Hye Myung, Kevin A. Tam, Sin‐jung Park, Ashley Cha, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 8 > 2 > 223 - 239

Although circulating tumor cells (CTCs) in blood have been widely investigated as a potential biomarker for diagnosis and prognosis of metastatic cancer, their inherent rarity and heterogeneity bring tremendous challenges to develop a CTC detection method with clinically significant specificity and sensitivity. With advances in nanotechnology, a series of new methods that are highly promising have...

article

Interaction between bound water molecules and local protein structures: A statistical analysis of the hydrogen bond structures around bound water molecules

Seungpyo Hong, Dongsup Kim

Proteins: Structure, Function, and Bioinformatics > 84 > 1 > 43 - 51

Water molecules play an important role in protein folding and protein interactions through their structural association with proteins. Examples of such structural association can be found in protein crystal structures, and can often explain protein functionality in the context of structure. We herein report the systematic analysis of the local structures of proteins interacting with water molecules,...

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INFONA - science communication portal

Search results for: Seungpyo Hong

Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway

Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti‐PDL1 efficacy in head and neck cancer

Branched, dendritic, and hyperbranched polymers in liquid biopsy device design

Cross‐decoration of dendritic cells by non‐inherited maternal antigen‐containing extracellular vesicles: Potential mechanism for PD‐L1‐based tolerance in cord blood and organ transplantation

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Gold nanoparticles in virus detection: Recent advances and potential considerations for SARS‐CoV‐2 testing development

Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Tumor penetration of Sub-10 nm nanoparticles: effect of dendrimer properties on their penetration in multicellular tumor spheroids

Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

35.1: Blue‐Diode Laser Annealing of Amorphous Silicon Films for Low‐Cost, Large‐Scale Manufacturing of Advanced Displays

Dendritic PEG outer shells enhance serum stability of polymeric micelles

57‐2: Scalable Crystallization of a‐Si Film on a Glass Substrate by Using a Blue Laser

KRDS: a web server for evaluating drug resistance mutations in kinases by molecular docking

Dendrimer‐based nanocarriers: a versatile platform for drug delivery

Low temperature polycrystalline silicon with single orientation on glass by blue laser annealing

Single plasmonic nanoparticles for ultrasensitive DNA sensing: From invisible to visible

Acquiring a Physical World and Serving Its Mirror World Simultaneously

Cover Image, Volume 8, Issue 2

Recent advances in nanotechnology‐based detection and separation of circulating tumor cells

Interaction between bound water molecules and local protein structures: A statistical analysis of the hydrogen bond structures around bound water molecules

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