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We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 μm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement...
Biological cells are characterized by highly complex phenomena and processes that are, to a great extent, interdependent. To gain detailed insights, devices designed to study cellular phenomena need to enable tracking and manipulation of multiple cell parameters in parallel; they have to provide high signal quality and high-spatiotemporal resolution. To this end, we have developed a CMOS-based microelectrode...
Various CMOS-based micro-electrode arrays (MEAs) have been developed in recent years for extracellular electrophysiological recording/stimulation of electrogenic cells [1–5]. Mostly two approaches have been used: (i) the active-pixel approach (APS) [2–4], which features simultaneous readout of all electrodes, however, at the expense of a comparably high noise level, and (ii) the switch-matrix (SM)...
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