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In freely moving rats finasteride markedly reduced the cortical content of allopregnanolone. This treatment significantly prolonged the increase in the extracellular concentration of dopamine in the prefrontal cortex induced by foot shock. Moreover, finasteride enhanced both maximal increase of dopamine and its duration elicited by a single injection of the anxiogenic drug FG 7142. These results suggest...
To study the effects of allopregnanolone (AP) depletion on stress-induced dopamine changes in cortical dopamine, the 5α-reductase inhibitor finasteride on a gram-scale is required. Two procedures for the extraction of finasteride from tablets are outlined (method A and B). In method A, a suspension of powdered tablets was preliminary extracted with chloroform and the extracts dried and evaporated...
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