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Cyclodextrin (CD)-containing polycations are prepared bycopolymerization of3A3B-dideoxy-3A,3B-diamino-β- and γ-CDs with dimethyl suberimidate·2HCl to yieldpolyamidine products. Both alkyl- and alkoxy-diamines are used to vary the spacing between the CDand the amidine charge centers. It is found that the transfection efficiency andtoxicity of such polycations is dramatically affected by the structure...
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