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Rationale Mephedrone is a commonly abused constituent of “bath salts” and has many pharmacological effects in common with methamphetamine. Despite their structural similarity, mephedrone differs significantly from methamphetamine in its effects on core body temperature and dopamine nerve endings. The reasons for these differences remain unclear. Objectives Mephedrone elicits a transient hypothermia...
The experimental basis for the formation of alkene radical cations by the heterolysis of alkyl radicals bearing leaving groups at the β position is reviewed, and a general mechanism involving contact alkene radical cation/anion pairs is presented for both fragmentation reactions and rearrangements. The available kinetic data for both fragmentations and migrations are summarized. The β-(acyloxy)alkyl...
The genesis and development of the 4,6-O-benzylidene acetal method for the preparation of β-mannopyranosides are reviewed. Particular emphasis is placed on the influence of the various protecting groups on stereoselectivity and these effects are interpreted in the framework of a general mechanistic scheme invoking a series of solvent-separated and contact ion pairs in dynamic equilibrium with a covalent...
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