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Phospholipase C‐η (PLCη) enzymes are a class of phosphatidylinositol 4,5‐bisphosphate‐hydrolyzing enzymes involved in intracellular signaling. PLCη2 can sense Ca2+ (stimulated by ∼1 µM free Ca2+) suggesting that it can amplify transient Ca2+ signals. PLCη enzymes possess an EF‐hand domain composed of two EF‐loops; a canonical 12‐residue loop (EF‐loop 1) and a non‐canonical 13‐residue loop (EF‐loop...
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