Search results for: Yan Du

Items from 1 to 20 out of 447 results

article

USP1‐mediated deubiquitination of KDM1A promotes the malignant progression of triple‐negative breast cancer

Yang Su, Yan Du, Wenguang He

Journal of Biochemical and Molecular Toxicology > 38 > 10 > n/a - n/a

Previous research has indicated the highly expressed lysine‐specific histone demethylase 1A (KDM1A) in several human malignancies, including triple‐negative breast cancer (TNBC). However, its detailed mechanisms in TNBC development remain poorly understood. The mRNA levels of KDM1A and Yin Yang 1 (YY1) were determined by RT‐qPCR analysis. Western blot was performed to measure KDM1A and ubiquitin‐specific...

article

Orbital‐Morphology‐Based Oxygen Reduction in a Correlated Oxide

Zhihua Zhang, Yangyu Zhu, Xiaoyue Shi, Baotong Qi, more

Advanced Functional Materials > 34 > 29 > n/a - n/a

Orbital degree of freedom plays a crucial role in governing the physical and chemical properties of solid materials, and it is widely investigated in the fields of physics, material science, and chemistry. Typically, orbital‐energy‐related scenarios, such as d‐band center or electron occupancy, have been discussed in the catalytic materials, since they can control the surface‐adsorbate bonding strength...

article

π–π Stacking Modulation via Polymer Adsorption for Elongated Exciton Diffusion in High‐Efficiency Thick‐Film Organic Solar Cells

Zhen Fu, Jia‐Wei Qiao, Feng‐Zhe Cui, Wen‐Qing Zhang, more

Advanced Materials > 36 > 21 > n/a - n/a

Developing efficient organic solar cells (OSCs) with thick active layers is crucial for roll‐to‐roll printing. However, thicker layers often result in lower efficiency. This study tackles this challenge using a polymer adsorption strategy combined with a layer‐by‐layer approach. Incorporating insulator polystyrene (PS) into the PM6:L8‐BO system creates PM6+PS:L8‐BO blends, effectively suppressing...

article

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Yichen Liu, Yidan Tang, Yin Bao, Kaiwei Cai, more

Angewandte Chemie International Edition > 63 > 19 > n/a - n/a

In order to realize portable pathogen diagnostics with easier quantitation, digitization and integration, we develop a ready‐to‐use electrochemical sensing strategy (Iso‐E‐Codelock) for real‐time detection of isothermal nucleic acid amplification. Bridged by a branched DNA as codelock, the isothermal amplicon is transduced into increased current of an electrochemical probe, holding multiple advantages...

article

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Yichen Liu, Yidan Tang, Yin Bao, Kaiwei Cai, more

Angewandte Chemie > 136 > 19 > n/a - n/a

article

Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab

Si Chen, Guoliang Zhang, Yiwen Liu, Cuixia Yang, more

The FEBS Journal > 291 > 8 > 1719 - 1731

Trastuzumab is widely used in human epidermal growth factor receptor 2 (HER2)‐positive gastric cancer (GC) therapy, but ubiquitous resistance limits its clinical application. In this study, we first showed that CD44 antigen is a significant predictor of overall survival for patients with HER2‐positive GC. Next, we found that CD44 could be co‐immunoprecipitated and co‐localized with HER2 on the membrane...

article

The Ras GTPase‐activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens

Huijuan Cao, Hao Gong, Mina Yu, Xiayan Pan, more

Molecular Plant Pathology > 25 > 3 > n/a - n/a

Ras GTPase‐activating proteins (Ras GAPs) act as negative regulators for Ras proteins and are involved in various signalling processes that influence cellular functions. Here, the function of four Ras GAPs, UvGap1 to UvGap4, was identified and analysed in Ustilaginoidea virens, the causal agent of rice false smut disease. Disruption of UvGAP1 or UvGAP2 resulted in reduced mycelial growth and an increased...

article

Sonographic features of diffuse giant cell tumor of the tendon sheath in the shoulder: A case report

Yan Du, Li Li, Xiaoling Hu

Journal of Clinical Ultrasound > 52 > 3 > 338 - 340

A middle‐aged woman presented to our hospital with a chief complaint of a mass on the left shoulder for 1 year. The initial lump was small with no pain or tenderness, and the patient had not sought medical attention for numbness in the left shoulder. Clinical examination showed a mass on the left shoulder measuring 11 × 8 × 3 cm approximately with no apparent skin damage or ecchymosis. No limitations...

article

Elevation of IL‐17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders

Kailey E. Brodeur, Meng Liu, Daniel Ibanez, Mareike J. Groot, more

Arthritis & Rheumatology > 76 > 2 > 285 - 292

Objective Kawasaki disease (KD) is a systemic vasculitis of young children that can lead to development of coronary artery aneurysms. We aimed to identify diagnostic markers to distinguish KD from other pediatric inflammatory diseases. Methods We used the proximity extension assay to profile proinflammatory mediators in plasma samples from healthy pediatric controls (n = 30), febrile controls (n = 26),...

article

Dual Mode TENG with Self‐Voltage Multiplying Circuit for Blue Energy Harvesting and Water Wave Monitoring

Chuncai Shan, Wencong He, Huiyuan Wu, Shaoke Fu, more

Advanced Functional Materials > 33 > 47 > n/a - n/a

As the most extensive natural energy on earth, ocean wave energy is regarded as a difficult energy to be fully and efficiently utilized because of its low frequency and multi‐direction movement. Herein, a versatile blue energy triboelectric nanogenerator (VBE‐TENG) fabricated by using dual‐mode output terminals with charge excitation strategy is reported, which can harvest varying water‐wave energy...

article

Boosting Output Performance of Sliding Mode Triboelectric Nanogenerator by Shielding Layer and Shrouded‐Tribo‐Area Optimized Ternary Electrification Layered Architecture

Shanshan An, Shaoke Fu, Wencong He, Gui Li, more

Small > 19 > 45 > n/a - n/a

Sliding mode triboelectric nanogenerator (S‐TENG) is effective for low‐frequency mechanical energy harvesting owing to their more efficient mechanical energy extraction capability and easy packaging. Ternary electrification layered (TEL) architecture is proven useful for improving the output performance of S‐TENG. However, the bottleneck of electric output is the air breakdown on the interface of...

article

Nanozyme‐Cosmetic Contact Lenses for Ocular Surface Disease Prevention

Quanyi Liu, Sheng Zhao, Yihong Zhang, Qi Fang, more

Advanced Materials > 35 > 44 > n/a - n/a

Efficiently balancing excess reactive oxygen species (ROS) caused by various factors on the ocular surface is a promising strategy for preventing the development of ocular surface diseases (OSDs). Nevertheless, the conventional topical administration of antioxidants is limited in efficacy due to poor absorption, rapid metabolism, and irreversible depletion, which impede their performance. To address...

article

Tunable Fluorescence and Morphology of Aggregates Built from a Mechanically Bonded Amphiphilic Bistable [2]Rotaxane

Jun‐Tao Shi, Xian‐Hui Chen, Yuan‐Yuan Peng, Gui‐Ping Wang, more

Chemistry – A European Journal > 29 > 59 > n/a - n/a

Advanced Organic Chemical Materials Co‐constructed Mechanically bonded amphiphiles (MBAs), also known as mechanically interlocked molecules (MIMs), have emerged as an important kind of functional building block for the construction of artificial molecular machines and soft materials. Herein, a novel MBA, i. e., bistable [2]rotaxane H2 was designed and synthesized. In the solution state, H2 demonstrated...

article

Conversion of Dielectric Surface Effect into Volume Effect for High Output Energy

Shaoke Fu, Huiyuan Wu, Wencong He, Qianying Li, more

Advanced Materials > 35 > 40 > n/a - n/a

Improving the output energy and durability of triboelectric nanogenerators (TENGs) remains a considerable challenge for their practical applications. Owing to the interface effect of triboelectrification and electrostatic induction, thinner films with higher dielectric constants yield a higher output; however, they are not durable for practical applications. Herein, the dielectric surface effect is...

article

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

Xiao‐xiao Zheng, Ding‐xiang Li, Ya‐ting Li, Yu‐lang Chen, more

Phytotherapy Research > 37 > 8 > 3195 - 3210

Elevations in circling branched‐chain amino acids (BCAAs) levels associated with insulin resistance and type 2 diabetes mellitus (T2DM). Morus alba L. water extracts (MLE) show hypoglycemic function, but the precise mechanism remains obscure. This study is designed to investigate the association of the antidiabetes effect of MLE with the BCAAs co‐metabolism modulated by host and gut microbiota. Tissue‐specific...

article

Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy

Wanling Liu, Yihong Zhang, Gen Wei, Minxuan Zhang, more

Angewandte Chemie International Edition > 62 > 33 > n/a - n/a

Senescent cells are the critical drivers of atherosclerosis formation and maturation. Mitigating senescent cells holds promise for the treatment of atherosclerosis. In an atherosclerotic plaque microenvironment, senescent cells interact with reactive oxygen species (ROS), promoting the disease development. Here, we hypothesize that a cascade nanozyme with antisenescence and antioxidant activities...

article

Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy

Wanling Liu, Yihong Zhang, Gen Wei, Minxuan Zhang, more

Angewandte Chemie > 135 > 33 > n/a - n/a

article

Impact of the Interdecadal Pacific Oscillation on tropical Indian Ocean sea surface height: An assessment from CMIP6 models

Veeranjaneyulu Chinta, Yan Du, Yu Hong, Zesheng Chen, more

International Journal of Climatology > 43 > 10 > 4631 - 4647

This study examined the sea level (SL) changes on the interdecadal timescale in the tropical Indian Ocean (TIO) in response to the Interdecadal Pacific Oscillation (IPO) in 20 Coupled Model Intercomparison Project Phase 6 (CMIP6) models. The analysis suggests that the interdecadal sea level pattern variation in the Thermocline Ridge of the Indian Ocean (TRIO) area coincides with the IPO phases and...

article

A Nanogenerator Enabled by a Perfect Combination and Synergetic Utilization of Triboelectrification, Charge Excitation and Electromagnetic Induction to Reach Efficient Energy Conversion

Gui Li, Jian Wang, Shaoke Fu, Chuncai Shan, more

Advanced Functional Materials > 33 > 14 > n/a - n/a

Triboelectric–electromagnetic hybridized nanogenerator (TEHG) is confirmed as an effective energy harvesting for Internet of Things. However, it is still a great challenge to gain a high‐output triboelectric‐nanogenerator (TENG) and to perfectly combine TENG with electromagnetic generator (EMG). Herein, a TEHG composed of space confined multi‐layer‐stack TENG (SM‐TENG) and stack compression promoted...

article

Identification of Three Different Phenotypes in Anti–Melanoma Differentiation–Associated Gene 5 Antibody–Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease

Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, more

Arthritis & Rheumatology > 75 > 4 > 609 - 619

Objective There is substantial heterogeneity among the phenotypes of patients with anti–melanoma differentiation–associated gene 5 antibody–positive (anti‐MDA5+) dermatomyositis (DM), hindering disease assessment and management. This study aimed to identify distinct phenotype groups in patients with anti‐MDA5+ DM and to determine the utility of these phenotypes in predicting patient outcomes. Methods...

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INFONA - science communication portal

Search results for: Yan Du

USP1‐mediated deubiquitination of KDM1A promotes the malignant progression of triple‐negative breast cancer

Orbital‐Morphology‐Based Oxygen Reduction in a Correlated Oxide

π–π Stacking Modulation via Polymer Adsorption for Elongated Exciton Diffusion in High‐Efficiency Thick‐Film Organic Solar Cells

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab

The Ras GTPase‐activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens

Sonographic features of diffuse giant cell tumor of the tendon sheath in the shoulder: A case report

Elevation of IL‐17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders

Dual Mode TENG with Self‐Voltage Multiplying Circuit for Blue Energy Harvesting and Water Wave Monitoring

Boosting Output Performance of Sliding Mode Triboelectric Nanogenerator by Shielding Layer and Shrouded‐Tribo‐Area Optimized Ternary Electrification Layered Architecture

Nanozyme‐Cosmetic Contact Lenses for Ocular Surface Disease Prevention

Tunable Fluorescence and Morphology of Aggregates Built from a Mechanically Bonded Amphiphilic Bistable [2]Rotaxane

Conversion of Dielectric Surface Effect into Volume Effect for High Output Energy

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy

Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy

Impact of the Interdecadal Pacific Oscillation on tropical Indian Ocean sea surface height: An assessment from CMIP6 models

A Nanogenerator Enabled by a Perfect Combination and Synergetic Utilization of Triboelectrification, Charge Excitation and Electromagnetic Induction to Reach Efficient Energy Conversion

Identification of Three Different Phenotypes in Anti–Melanoma Differentiation–Associated Gene 5 Antibody–Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease

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