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Photoaktivierbare multivalente trisNTA‐Verbindungen ermöglichen die räumlich und zeitlich kontrollierte In‐situ‐Markierung und Assemblierung von His‐markierten Proteinen. Dieses minimalistische lichtaktivierbare Schlüssel‐Schloss‐System dient der Steuerung von nanomolaren Proteinwechselwirkungen wie Rezeptor‐Clusterbildung oder anderen biotechnologischen Anwendungen wie Multiprotein‐Chips.
Making light work: Photoactivatable multivalent trisNTA compounds have been developed for the in situ labeling and assembly of His‐tagged proteins in time and space (see picture). This small light‐tunable lock‐and‐key system offers the opportunity to trigger nanomolar protein interactions, such as receptor clustering, or biotechnological applications, for example, multiprotein arrays.
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