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Störungen im glucotropen Regelkreis führen zu einem Typ-2-Diabetes mellitus (T2DM). Neben der peripheren Insulinresistenz trägt zur Manifestation eine gestörte Insulinsekretion durch Dysfunktion der β-Zellen des Pankreas bei. β-Zellen messen durch Expression des Sensorproteins Glucokinase die Glucosekonzentration im Blut und passen dadurch die Insulinsekretion an den Ernährungszustand an. Eine regulierte...
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