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Quality standardization of herbal medicines (HMs) is an important task with great challenges. Selection of abundant compounds as markers is currently a major approach for the quality control of HMs; however, such marker compounds are irrelevant to the bioactivities in many cases. Taking Lycoridis Radiatae Bulbus (LRB) as an example, we proposed a universal strategy to identify the effective combinatorial...
A novel hierarchical chromatographic response function (HCRF)-directed orthogonal design procedure has been used for optimization of an high-performance liquid chromatography method for fingerprinting Mai-Luo-Ning (MLN) injection. The method was then successfully validated. Five major controllable chromatographic conditions at four levels were included in the orthogonal design. A total of 16 chromatographic...
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