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Triton X‐100 detergent treatment is a robust enveloped virus inactivation unit operation included in biopharmaceutical manufacturing processes. However, the European Commission officially placed Triton X‐100 on the Annex XIV authorization list in 2017 because a degradation product of Triton X‐100, 4‐(1,1,3,3‐tetramethylbutyl) phenol (also known as 4‐tert‐octylphenol), is considered to have harmful...
Triton X‐100 has long been used either alone or in combination with solvent to inactivate enveloped viruses in biopharmaceutical manufacturing. However, European Chemicals Agency (ECHA) officially placed Triton X‐100 on the Annex XIV authorization list in 2017 because 4‐(1,1,3,3‐tetramethylbutyl) phenol, a degradation product of Triton X‐100, is of harmful endocrine disrupting activities. As a result,...
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