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Online microdialysis-capillary electrophoresis (CE) was used to measure the changes in extracellular d-serine concentration in response to the application of glutamate agonists and antagonists in the rat striatum. The microdialysis-CE assay was capable of measuring concentration changes as small as 8% with a sampling rate of 12–15s. Kainic acid (KA) induced increases in d- and l-serine concentrations...
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