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The CDKN2A locus on human chromosome 9p21 encodes two tumor suppressors, p14 ARF and p16 INK4A , which enhance the growth-suppressive functions of the retinoblastoma (Rb) and the p53 proteins, respectively. Conversely, the E6 and E7 oncoproteins of the high-risk human papillomaviruses (HPVs) causally associated with carcinogenesis of the uterine cervix...
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