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Introduction: Although the src-family protein tyrosine kinase 59fyn has been implicated to be involved in TCR mediated signaling processes, its role during T-cell activation is so far poorly established. A major challenge in understanding the function of fyn will be the identification and characterisation of proteins that interact with fyn and serve as substrates for the kinase in vivo.Materials...
Introduction: Stimulation of T lymphocytes by antigen or anti T-cell receptor (TCR) antibodies causes rapid phosphorylation of several cellular proteins on tyrosine residues. Two src-family protein tyrosine kinases (PTKs), p56 lck and p59 fyn , have been implicated in the initiation of the TCR-induced signaling cascade. Whereas the requirement of Lck in TCR/CD3...
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