Search results for: Mandy B. Esch

Items from 1 to 7 out of 7 results

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Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

Courtney M. Sakolish, Mandy B. Esch, James J. Hickman, Michael L. Shuler, more

EBioMedicine > 2016 > 5 > Complete > 30-39

Organ-on-a-chip devices have gained attention in the field of in vitro modeling due to their superior ability in recapitulating tissue environments compared to traditional multiwell methods. These constructed growth environments support tissue differentiation and mimic tissue–tissue, tissue–liquid, and tissue–air interfaces in a variety of conditions. By closely simulating the in vivo biochemical...

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Endothelial retention and phenotype on carbonized cardiovascular implant surfaces

Christopher M. Frendl, Scott M. Tucker, Nadeem A. Khan, Mandy B. Esch, more

Biomaterials > 2014 > 35 > 27 > 7714-7723

Heart valve disease is an increasing clinical burden for which there is no effective treatment outside of prosthetic replacement. Over the last 20 years, clinicians have increasingly preferred the use of biological prosthetics to mechanical valves despite their superior durability because of the lifelong anticoagulation therapy that is required. Mechanical valve surface engineering has largely focused...

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How multi-organ microdevices can help foster drug development

Mandy B. Esch, Alec S.T. Smith, Jean-Matthieu Prot, Carlota Oleaga, more

Advanced Drug Delivery Reviews > 2014 > 69-70 > Complete > 158-169

Multi-organ microdevices can mimic tissue–tissue interactions that occur as a result of metabolite travel from one tissue to other tissues in vitro. These systems are capable of simulating human metabolism, including the conversion of a pro-drug to its effective metabolite as well as its subsequent therapeutic actions and toxic side effects. Since tissue–tissue interactions in the human body can play...

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Microphysiological systems and low-cost microfluidic platform with analytics

Alec St Smith, Christopher J Long, Bonnie J Berry, Christopher McAleer, more

Stem Cell Research & Therapy > 2013 > 4 > 1 > 1-5

A multiorgan, functional, human in vitro assay system or 'Body-on-a-Chip' would be of tremendous benefit to the drug discovery and toxicology industries, as well as providing a more biologically accurate model for the study of disease as well as applied and basic biological research. Here, we describe the advances our team has made towards this goal, as well as the most pertinent issues facing further...

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Promises, challenges and future directions of μCCAs

Mandy B. Esch, Jong H. Sung, Michael L. Shuler

Journal of Biotechnology > 2010 > 148 > 1 > 64-69

Micro-cell culture analogs (μCCAs) are a class of in vitro tissue analogs that combine multiple organ analogs on one microfluidic platform in physiologically correct volume ratios. The microfluidic platform also provides fluid flow rates and substance residence times close to those present in the human body. Several advantages arise from the microfluidic format that can be exploited for realistic...