Search results for: D. Lukasiewicz

Items from 1 to 12 out of 12 results

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Developmental Regulation and Activity-Dependent Maintenance of GABAergic Presynaptic Inhibition onto Rod Bipolar Cell Axonal Terminals

Timm Schubert, Mrinalini Hoon, Thomas Euler, Peter D. Lukasiewicz, more

Neuron > 2013 > 78 > 1 > 124-137

Presynaptic inhibition onto axons regulates neuronal output, but how such inhibitory synapses develop and are maintained in vivo remains unclear. Axon terminals of glutamatergic retinal rod bipolar cells (RBCs) receive GABA _A and GABA _C receptor-mediated synaptic inhibition. We found that perturbing GABAergic or glutamatergic neurotransmission does not prevent GABAergic synaptogenesis...

article

Identification of quantitative trait loci for body composition in two growth-differentiated mouse lines

D. Lukasiewicz-Smietanska, E. Wirth-Dzieciolowska, M. Gajewska

Annals of Warsaw University of Life Sciences - SGGW. Animal Science > 2010 > 47

Identification of quantitative trait loci for body composition in two growth-differentiated mouse lines. We performed a genome-wide quantitative trait locus (QTL) analysis of body composition at two lines L and C derived from the cross of four mice strains (A/St, C57BL/6, BALB/c, BN/a). Interval mapping revealed five suggestive QTLs for tail length, two QTLs for mesenteric fat and liver weight, one...

article

Identification of quantitative trait loci for body weight and body weight gain in two growth-differentiated mouse lines

D. Lukasiewicz-Smietanska, E. Wirth-Dzieciolowska, M. Gajewska

Annals of Warsaw University of Life Sciences - SGGW. Animal Science > 2009 > 46

Identification of quantitative trait loci for body weight and body weight gain in two growth-differentiated mouse lines. A genome wide quantitative trait locus (QTL) analysis was performed in two lines L and C derived from four mice strains (A.CA, C57BL/6, BALB/c, BN/a). This lines differed in body weight, behaviour, length of reproduction period, rate of ageing, degree survivability. Five statistically...

article

Premises and Main Claims of Theodicy by Bernard Bolzano

D. Lukasiewicz

Przeglad Filozoficzny - Nowa Seria (Philosophical Review - New Series) > 2007 > 16 > 1(61) > 223-238

The article presents the main logical and metaphysical assumptions of Bolzano's theodicy. The conception of truths in themselves is understood as a logical assumption of Bolzano's proposal, and the conception of substance is the metaphysical assumption of the theodicy in question. The world, according to Bolzano, is causally determined and it is also logically determined to the effect that the world...

article

Presynaptic Inhibition Modulates Spillover, Creating Distinct Dynamic Response Ranges of Sensory Output

Botir T. Sagdullaev, Maureen A. McCall, Peter D. Lukasiewicz

Neuron > 2006 > 50 > 6 > 923-935

Sensory information is thought to be modulated by presynaptic inhibition. Although this form of inhibition is a well-studied phenomenon, it is still unclear what role it plays in shaping sensory signals in intact circuits. By visually stimulating the retinas of transgenic mice lacking GABAc receptor-mediated presynaptic inhibition, we found that this inhibition regulated the dynamic range of ganglion...

article

God's Intermediate Knowledge: Freedom and Evil

D. Lukasiewicz

Przeglad Filozoficzny - Nowa Seria (Philosophical Review - New Series) > 2005 > 14 > 1(53) > 45-56

The author investigates the problem whether it is possible to adopt two tenets at the same time: one saying that God possesses prior knowledge of future contingent events, especially human acts, and another one saying that humans can act freely. These problems are discussed in a historical perspective. He analyses the paradigmatic conception of Saint Augustine presented in the 'De libero arbitrio'...

article

The Concept of 'Lebenswelt' in Husserl's Phenomenology

D. Lukasiewicz

Przeglad Filozoficzny - Nowa Seria (Philosophical Review - New Series) > 2005 > 14 > 2(54) > 149-162

The world of everyday life is a central concept in Husserl's philosophy. Its origins are not clear, however. It is often claimed that Husserl proposed the concept of 'Lebenswelt' rather unexpectedly (in 1936) and at the cost of destroying the continuity of his thought as a reaction to the growing popularity of the concept of 'Dasein' that had been introduced by Heidegger in the 'Being and time' (in...

article

GABAC receptor-mediated inhibition in the retina

Peter D. Lukasiewicz, Erika D. Eggers, Botir T. Sagdullaev, Maureen A. McCall

Vision Research > 2004 > 44 > 28 > 3289-3296

Inhibition at bipolar cell axon terminals regulates excitatory signaling to ganglion cells and is mediated, in part, by GABA _C receptors. We investigated GABA _C receptor-mediated inhibition using pharmacological approaches and genetically altered mice that lack GABA _C receptors. Responses to applied GABA showed distinct time courses in various bipolar cell classes, attributable...

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SOME COMMENTS ON METAETHICAL VIEWS OF K. TWARDOWSKI

D. Lukasiewicz

Etyka (Ethics) > 2004 > 37 > 215-226

The paper deals with some ambiguities in Twardowski's account of ethics. The author focuses on finding more accurate interpretation of Twardowski's views on values. In his attempt at fulfilling the task author quotes and later comments on some ways of understanding Twardowski's views. His major concern is with answering the question whether Twardowski finds value (good) a specific feature of an object,...

article

Value of cytological examinations in the diagnosis of lung cancer

M. Fijalkowski, J. Graczyk, I. Pawlowska, M. Szmidt, more

Lung Cancer > 1999 > 25 > Supplement 1 > S28

article

A diversity of GABA receptors in the retina

Peter D. Lukasiewicz, Colleen R. Shields

Seminars in Cell and Developmental Biology > 1998 > 9 > 3 > 293-299

GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABA _A and GABA _C receptors and the metabotropic GABA _B receptor. GABA _C receptors are enriched in the retina, compared to other parts of the CNS. GABA _C and GABA...

article

Immunocytochemical localization of polyamines in the tiger salamander retina

Tony L. Valentino, Peter D. Lukasiewicz, Carmelo Romano

Brain Research > 1996 > 713 > 1-2 > 278-285

The polyamines spermine and spermidine are present in neural tissue, but their functions there are not well understood. Recent work suggests that the NMDA subtype of glutamate receptors, other glutamate receptor subtypes, and certain K ⁺ -channels, are neural targets for polyamines. To better understand the neuron-specific roles of polyamines, we have developed antibodies that interact with...

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