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Standard dosing for individuals with hemophilia A is based on body weight such that 50 IU kg−1 is defined as a 100% dose, or one attaining 1.00 IU mL−1 factor VIII (FVIII) clotting activity. No guidelines exist, however, for individuals with hemophilia who are obese, body mass index (BMI) ≥ 30, who may actually be ‘over’‐treated based on higher in vivo recovery based on higher weight. Alternative...
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