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The mTOR-mediated PI3K/AKT/mTOR signal transduction pathway plays a key role in a broad spectrum of cancers. In the present article, QSAR and pharmacophore studies were carried out using a series of 61 benzothiazole class of PI3Kα inhibitors to characterize molecular features and structural requirements crucial for biological interaction. QSAR study performed using TSAR 3.3 by multiple regression...
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