Search results for: Mustapha Cherkaoui

Items from 1 to 20 out of 33 results

article

Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes

Saad Shaaban, Dominique Vervandier-Fasseur, Pierre Andreoletti, Amira Zarrouk, more

Bioorganic Chemistry > 2018 > 80 > C > 43-56

Here a new series of twenty-one organoselenides, of potential protective activity, were synthesized and tested for their intrinsic cytotoxicity, anti-apoptotic and antioxidant capacities in oligodendrocytes. Most of the organoselenides were able to decrease the ROS levels, revealing antioxidant properties. Compounds 5b and 7b showed a high glutathione peroxidase (GPx)-like activities, which were 1...

article

Chemical and phytochemical characterizations of argan oil (Argania spinosa L. skeels), olive oil (Olea europaea L. cv. Moroccan picholine), cactus pear (Opuntia megacantha salm-dyck) seed oil and cactus cladode essential oil

Youssef El Kharrassi, Nadia Maata, Mouaad Amine Mazri, Soufiane El Kamouni, more

Journal of Food Measurement and Characterization > 2018 > 12 > 2 > 747-754

The chemical and phytochemical characteristics of argan oil (Argania spinosa L. skeels), olive oil (Olea europaea L. cv. Moroccan picholine), cactus pear (Opuntia megacantha salm-dyck) seed oil and cactus cladode essential oil were investigated. The values for acidity varied from 0.28% in argan oil to 1.05% in olive oil. The peroxide values were between 2.26 and 2.84 meq O₂/kg oil while the coefficients...

article

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells

Meryam Debbabi, Amira Zarrouk, Maryem Bezine, Wiem Meddeb, more

Chemistry and Physics of Lipids > 2017 > 207 > PB > 151-170

Increased levels of 7-ketocholesterol (7KC), which results mainly from cholesterol auto-oxidation, are often found in the plasma and/or cerebrospinal fluid of patients with neurodegenerative diseases and might contribute to activation of microglial cells involved in neurodegeneration. As major cellular dysfunctions are induced by 7KC, it is important to identify molecules able to impair its side effects...

article

Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes

Maryem Bezine, Meryam Debbabi, Thomas Nury, Rym Ben-Khalifa, more

Chemistry and Physics of Lipids > 2017 > 207 > PB > 135-150

Imbalance in the homeostasis of K⁺ ions has been reported to contribute to the pathogenesis of neurodegenerative diseases. 7-ketocholesterol (7KC), 24S-hydroxycholesterol (24S-OHC), and tetracosanoic acid (C24:0), often found at increased levels in patients with Alzheimer’s disease, Multiple Sclerosis and X-ALD, are able to trigger numerous nerve cell dysfunctions. We therefore studied the impact...

article

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes

Amira Zarrouk, Thomas Nury, El-Mostafa Karym, Anne Vejux, more

The Journal of Steroid Biochemistry and Molecular Biology > 2017 > 169 > C > 29-38

Mitochondrial dysfunctions and oxidative stress are involved in several non demyelinating or demyelinating neurodegenerative diseases. Some of them, including multiple sclerosis (MS), are associated with lipid peroxidation processes leading to increased levels of 7-ketocholesterol (7KC). So, the eventual protective effect of dimethylfumarate (DMF), which is used for the treatment of MS, was evaluated...

article

Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

Norbert Latruffe, Allan Lançon, Raffaele Frazzi, Virginie Aires, more

Annals of the New York Academy of Sciences > 1348 > 1 > 97 - 106

This review presents recent evidence implicating microRNAs (miRNAs) in the beneficial effects of resveratrol (trihydroxystilbene), a nonflavonoid plant polyphenol, with emphasis on its anti‐inflammatory effects. Many diseases and pathologies have been linked, directly or indirectly, to inflammation. These include infections, injuries, atherosclerosis, diabetes mellitus, obesity, cancer, osteoarthritis,...

article

An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system

Asmaa Badreddine, El Mostafa Karym, Amira Zarrouk, Thomas Nury, more

Steroids > 2015 > 99 > PB > 119-124

Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and mitochondrial activity were evaluated on 158N murine oligodendrocytes, C6 rat glioma cells, and SK-N-BE human neuronal cells with the crystal violet test...

article

Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells

Youssef El Kharrassi, Mohammad Samadi, Tatiana Lopez, Thomas Nury, more

Biochemical and Biophysical Research Communications > 2014 > 446 > 3 > 798-804

The objective of this study was to evaluate the biological activities of the major phytosterols present in argan oil (AO) and in cactus seed oil (CSO) in BV2 microglial cells. Accordingly, we first determined the sterol composition of AO and CSO, showing the presence of Schottenol and Spinasterol as major sterols in AO. While in CSO, in addition to these two sterols, we found mainly another sterol,...

article

The human peroxisome in health and disease: The story of an oddity becoming a vital organelle

Joseph Vamecq, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Norbert Latruffe

Biochimie > 2014 > 98 > Complete > 4-15

Since the first report by Rhodin in 1954, our knowledge on mammalian microbodies/peroxisomes has known several periods. An initial two decades period (1954–1973) has contributed to the biochemical individualisation of peroxisomes as a new class of subcellular organelles (de Duve, 1965). The corresponding research period failed to define a clear role of mammalian peroxisomes in vital functions and...

article

A tribute to Christian de Duve (1917–2013)

Mustapha Cherkaoui-Malki

Biochimie > 2014 > 98 > Complete > 1-3

article

LXR antagonists induce ABCD2 expression

Catherine Gondcaille, Emmanuelle C. Genin, Tatiana E. Lopez, Alexandre M.M. Dias, more

BBA - Molecular and Cell Biology of Lipids > 2014 > 1841 > 2 > 259-266

X-linked adrenoleukodystrophy (X-ALD) is a rare neurodegenerative disorder characterized by the accumulation of very-long-chain fatty acids resulting from a β-oxidation defect. Oxidative stress and inflammation are also key components of the pathogenesis. X-ALD is caused by mutations in the ABCD1 gene, which encodes for a peroxisomal half ABC transporter predicted to participate in the entry of VLCFA-CoA...

article

Diacylglycerol-containing oleic acid induces increases in [Ca2+]i via TRPC3/6 channels in human T-cells

Celia Carrillo, Aziz Hichami, Pierre Andreoletti, Mustapha Cherkaoui-Malki, more

BBA - Molecular and Cell Biology of Lipids > 2012 > 1821 > 4 > 618-626

Though most of the studies have focused on the effects of free fatty acids on T-cell activation, fatty acids incorporated into plasma membrane phospholipids may also affect cell signaling via diacylglycerol (DAG), generally produced by phospholipid hydrolysis. In the present study, we have synthesized a DAG-containing oleic acid and studied its implication in the modulation of calcium signaling in...

article

Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

Jiansheng Huang, Navin Viswakarma, Songtao Yu, Yuzhi Jia, more

The American Journal of Pathology > 2011 > 179 > 2 > 703-713

Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1 ^−/− ) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferation, and hepatocellular carcinomas. Deficiency of ACOX1 results in unmetabolized substrates of this enzyme that function as biological ligands for peroxisome proliferator-activated...

article

Electrochemical probe for the monitoring of DNA–protein interactions

Rita Meunier-Prest, Alice Bouyon, Eve Rampazzi, Suzanne Raveau, more

Biosensors and Bioelectronics > 2010 > 25 > 12 > 2598-2602

Self-assembly of thiol-terminated oligonucleotides on gold substrates provides a convenient way for DNA-functionalized surfaces. Here we describe the development of an electrochemical assay for the detection of DNA–protein interactions based on the modification of the electrochemical response of methylene blue (MB) intercalated in the DNA strands. Using a functionalized electrode with double stranded...

article

Structural and Catalytic Properties of the D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas aeruginosa

Driss Mountassif, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Norbert Latruffe, more

Current Microbiology > 2010 > 61 > 1 > 7-12

To put forward BDH from Pseudomonas aeruginosa’s enzymatic properties, we report a two-step purification of BDH and its gene sequencing allowing the investigation of its structural properties. Purification of BDH was achieved, using ammonium sulfate fractionation and Blue Sepharose CL-6B affinity chromatography. SDS–PAGE analysis reveals a MM of 29 kDa, whereas the native enzyme showed a MM of 120 kDa...

article

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Mustapha Cherkaoui, Abderrahim Boutalib

Open Chemistry > 2009 > 7 > 3 > 328-336

The reaction mechanism between AlX and HX (X = Br, Cl, and F) have been characterized in detail using DFT as well as the ab initio method. The reaction yielding AlX3 and molecular hydrogen was calculated to be highly exothermic. The present calculations also show that the possible routes to the trihalides species start more favorable with the primary insertion product AlX2H than with the biadduct...

article

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Mustapha Cherkaoui, Abderrahim Boutalib

Open Chemistry > 2009 > 7 > 3 > 328-336

article

Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line

Nicolas Cabaton, Coralie Dumont, Isabelle Severin, Elisabeth Perdu, more

Toxicology > 2009 > 255 > 1-2 > 15-24

Human can be exposed to bis(hydroxyphenyl)methane (bisphenol F or BPF) and its derivatives as environment and food’s contaminants. This study was investigated to identify and to compare toxic potency of BPF, BFDGE, and two of BPF metabolites using in vitro methods. BPF did not induce any genic mutation in bacteria when the Ames test was performed according to the OECD guideline. In contrast, using...

article

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Mustapha Cherkaoui, Abderrahim Boutalib

Central European Journal of Chemistry > 2009 > 7 > 3 > 328-336

The reaction mechanism between AlX and HX (X = Br, Cl, and F) have been characterized in detail using DFT as well as the ab initio method. The reaction yielding AlX₃ and molecular hydrogen was calculated to be highly exothermic. The present calculations also show that the possible routes to the trihalides species start more favorable with the primary insertion product AlX₂H than with the biadduct...

article

Theoretical study of the reactions of AlF with HCl: Reaction pathways

Mustapha Cherkaoui, Abderrahim Boutalib

Journal of Molecular Structure: THEOCHEM > 2008 > 848 > 1-3 > 139-143

The mechanisms for the reactions of AlF with HCl have been characterized in detail using DFT as well as the ab initio method, including zero-point corrections. From the potential energy profile it can be predicted that the reaction process of forming the new Al(III) hydride HAlFCl compound for this reaction is spontaneous with a low activation energy barrier. The reaction yielding to AlFCl ₂ ...

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INFONA - science communication portal

Search results for: Mustapha Cherkaoui

Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes

Chemical and phytochemical characterizations of argan oil (Argania spinosa L. skeels), olive oil (Olea europaea L. cv. Moroccan picholine), cactus pear (Opuntia megacantha salm-dyck) seed oil and cactus cladode essential oil

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells

Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes

Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system

Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells

The human peroxisome in health and disease: The story of an oddity becoming a vital organelle

A tribute to Christian de Duve (1917–2013)

LXR antagonists induce ABCD2 expression

Diacylglycerol-containing oleic acid induces increases in [Ca2+]i via TRPC3/6 channels in human T-cells

Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

Electrochemical probe for the monitoring of DNA–protein interactions

Structural and Catalytic Properties of the D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas aeruginosa

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line

Theoretical determination of the favorable mechanism of the reaction between AlX and HX (X = Br, Cl, and F)

Theoretical study of the reactions of AlF with HCl: Reaction pathways

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