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Background Kidney stones and their risk factors aggregate in families, yet few studies have estimated the heritability of known risk factors. Objective Estimate the heritability of dietary risk factors for kidney stones. Methods Dietary intakes were assessed using the Viocare Food Frequency Questionnaire in sibships enrolled in the Rochester, MN cohort of the Genetic Epidemiology Network of Arteriopathy...
Alkaline phosphatase (ALP) is an enzyme critical for physiological and pathological biomineralization. Experiments were designed to determine whether ALP participates in the formation of calcifying nanometer sized particles (NPs) in vitro. Filtered homogenates of human calcified carotid artery, aorta and kidney stones were inoculated into cell culture medium containing 10% fetal bovine serum in the...
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